Peptide Therapy
Peptides are short strings of amino acids, typically comprising 2-40 amino acids. We offer a range of peptide protocols that are all designed to achieve different goals, such as sleep quality or fat loss. This is a cutting-edge form of modern medicine that is designed to help you optimize your health and performance.
Peptide Therapy
- Hormone production and signaling
- Communications between cells
- Wound and tissue healing and regeneration
- Immune functions
- Metabolic functions
- Brain and neurological functions
- Physical and cognitive performance
- Reproductiion and sexual health
- Anti-aging processes, such as autophagy and Sirtuin pathways
- Mitochondrial function
- Anabolic processes such as muscle building
- Sleep and circadian rhythm
Therapeutic peptides are made in the lab to function like natural peptides do in your body. They may be identical to the natural version or chemically improved to make them safer or more effective.
Because your body naturally recognizes and works with peptides, they are safe and deliver powerful clinical results when taken at the right dosages, combination, and timing. Depending on your health goals and type of peptides, they may work best orally, intravenously, or through subcutaneous injections. Most therapeutic peptides are administered through subcutaneous injections.
To date, over 7,000 naturally-occurring peptides have been identified. Because peptides are mostly naturally occurring in the body, they are typically extremely well-tolerated and very safe. Dr. Koniver has discovered that peptides work best when administered together in specific combinations to enhance the synergy and effectiveness of each peptide.
Doctor Formulated
It can take a great deal of clinical expertise to design the right personalized peptide protocols for the right health goals. Our therapeutic peptide protocols are developed and based on a deep understanding of human physiology and 20+ years of clinical experience in performance medicine.
Dosage Cycling & Tapering
Without cycling or tapering, your body can get accustomed to the effects of the peptides, so the benefits diminish over time. We build in variability in peptide uses and dosages to maximize the health benefits you get for the money you pay.
Convenience
Since most peptide products are available as research chemicals, you’d typically have to calculate the right amounts of water to add and volume to inject in order to get the right dosages. Then, you’ll also have to load the needles with minimal air bubbles.
Potency
For peptides to work, your products have to have the same potency as indicated on the label. Peptides are more fragile molecules that break down more easily with the wrong handling protocols and heat exposure. So, without careful quality control, you can easily lose potency. In addition to third-party testing, we ship our peptide products overnight on ice to ensure that it reaches you at full potency.
Koniver Wellness serves hundreds of elite international clients who trust us for the quality and safety of our products. Our peptides come from a cGMP-certified pharmaceutical producer who follows the highest manufacturing standards.
Cofactors
We’re experts in synergistic stacks, both from research and having worked with thousands of patients. Many peptides work better or produce longer-lasting results once you provide additional nutrients as building blocks or cofactors. In many of our therapeutic peptide protocols, we add these additional cofactors to boost the peptides’ effectiveness. We also often recommend nutrient IV therapy to maximize the effectiveness of your protocol.
Purity
Since you’re injecting these peptides into your body, you want to ensure that they’re free of dangerous contaminants. The more popular a health product category becomes, the more vendors emerge that don’t follow the highest standards, and products may contain unhealthy ingredients or contaminants. Peptides are no exception, especially if you’re purchasing them as research chemicals that can legally contain harmful substances.
All of these become even more complicated and cumbersome if you’re using multiple peptides, or if you need multiple injections throughout the day. Our peptides come in 30-day supplies premixed and loaded in insulin needles ready for injections, so you can skip all the cumbersome steps and be confident you’re getting the right doses.
HOW DO PEPTIDES HELP?
Dr. Koniver has been utilizing a variety of peptides with his clients for years and has studied their effectiveness and safety. While these peptides are very very safe (no side effects), the efficacy is greatly enhanced when certain peptides are combined together.
To enhance the compliance and effectiveness for these peptides to successfully help his clients, Dr. Koniver formulated a myriad of peptide protocols to optimize aspects of our life.
- 20+ years of real-world clinical experience in performance medicine.
- Deep understanding of human physiology and science behind each peptide.
- Clinically proven in thousands of Dr. Koniver’s own clients and those of his 100+ physician mentees.
- Reaps synergistic benefits between peptides, both physiologically and pharmacokinetically.
- Minimizes side effects and tolerance.
- Provides both immediate and long-lasting results.
- Maximizes benefits by combining peptides with other nutrients or building blocks.
- Minimizes the guesswork of peptide math, mixing, and combining.
- Achieves the desired results in 1 - 2 daily injections.
Elevation Member Price: $279
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Each protocol includes individual peptides. Click on each individual peptide for more information. If you have any questions about the pricing or would like to schedule an appointment, contact us now!
What is ARA 290 and how does it work?
ARA 290 is an 11-amino acid peptide designed and based on a portion of the hormone erythropoietin, which stimulates red blood cell production. However, ARA 290 does not stimulate red blood cell production, but rather it stimulates tissue repair and protection [R].
Clinical trials found that ARA 290 improves metabolic control and neuropathic symptoms in type 2 diabetics and sarcoidosis patients [R].
Benefits and uses of ARA 290
- Promotes healthy blood sugar control
- Protects neurons from oxidative stress
- Protects heart tissues
- Promotes a balanced inflammatory response
- Normalizes excess nociceptor (pain neuron) signaling in neuropathic pain
Side effects
No side effects of ARA 290 have been reported in clinical trials.
Stacks well with:
Other anti-inflammatory and neuroregenerative peptides
Ways to take:
Subcutaneous injection
What is BPC-157 and how does it work?
BPC-157 is a peptide with numerous uses. It is a 15-amino acid peptide derived from body protection compound (BPC) found in human stomach digestive juices. Studies show it accelerates healing of many tissues, including those that typically heal slowly, such as tendons and ligaments.
BPC-157 seems to also balance systemic inflammation, increase blood flow to damaged tissues, and relieve pain.
Benefits and uses of BPC-157
- Accelerates wound, skin, and tissue healing, including deep burns, ligaments, bones, and tendons
- Protects and heals gut lining
- Promotes many types of cellular repair
- Protects cells and improves cell survival with oxidative stress
- Improves blood flow to injured areas
- Relieves pain from injuries
- Protects neurons and supports healing of brain injuries
- Regulates brain serotonin and dopamine functions, possibly helping with mood
- Improves blood vessel formation
- May help with stress urinary incontinence
- Supports a healthy gut-brain axis
- Supports muscle building in response to resistance training
Side effects
- Temporary pain/redness/bruises/burning sensation at injection site
- Temporary fatigue and lethargy right after injection, so some people may use it at bedtime
- Rare and temporary side effects include nausea, dizziness, appetite changes, hot or cold flashes, and headache
Ways to take:
Oral, subcutaneous, Intra-articular
BPC-157 is a systemic peptide, so any route and location of administration will benefit the entire body. However, it may be best to administer near the location that needs the healing. So, taking it orally is better for gut healing purposes.
Part of Koniver Protocols
- Remedy
- Flow
- Revive
- Apex
- Equilibrium
- Glow
- Fat loss
- Performance
GHRH/MOD GRF(1-29) with DAC
What is CJC-1295 and how does it work?
Growth hormone is a natural peptide hormone from your pituitary gland. In young children, it stimulates growth. In adults, it supports muscle mass, fat metabolism, bone health, and heart health. It typically increases during deep sleep in the middle of the night. Also, its levels decline with age, contributing to age-related body fat gain, loss of lean mass, and slowed metabolism.
Growth hormone also stimulates IGF-1, which manages the effects of growth hormones. Both hormones work together on tissue and bone growth. IGF-1 weakly binds to insulin receptors and may enhance insulin action. In adults, IGF-1 also protects the blood vessels and neurons, making it important for cardiovascular, and cognitive and mental health.
CJC-1295 is the synthetic analog of the first 29 amino acids of growth-hormone releasing hormone (GHRH) or growth hormone secretagogue. In a clinical study, CJC-1295 increased growth hormones (GH) by 2- to 10-fold and insulin growth factor-1 (IGF-1) by 0.5- to 3-fold over the course of 9 to 11 days.
Benefits and uses of BPC-157
- Promotes muscle growth and fat loss
- Slows down aging
- Improves sleep
- Stays in the system for more than a week
- Temporarily increases GHRH
Stacks well with:
Other growth hormone secretagogue peptides, with synergistic actions.
Ways to take:
Subcutaneous
Part of Koniver Protocols
- Neuroregen
- Flow
- Fat Loss
- Strength
- Performance
GHRH/MOD GRF(1-29) with DAC
What is CJC-1295 and how does it work?
Growth hormone is a natural peptide hormone from your pituitary gland. In young children, it stimulates growth. In adults, it supports muscle mass, fat metabolism, bone health, and heart health. It typically increases during deep sleep in the middle of the night. Also, its levels decline with age, contributing to age-related body fat gain, loss of lean mass, and slowed metabolism.
Growth hormone also stimulates IGF-1, which manages the effects of growth hormones. Both hormones work together on tissue and bone growth. IGF-1 weakly binds to insulin receptors and may enhance insulin action. In adults, IGF-1 also protects the blood vessels and neurons, making it important for cardiovascular, and cognitive and mental health.
CJC-1295 is the synthetic analog of the first 29 amino acids of growth-hormone releasing hormone (GHRH) or growth hormone secretagogue. In a clinical study, CJC-1295 increased growth hormones (GH) by 2- to 10-fold and insulin growth factor-1 (IGF-1) by 0.5- to 3-fold over the course of 9 to 11 days.
Benefits and uses of CJC 1295
- Promotes muscle growth and fat loss
- Slows down aging
- Improves sleep
- Stays in the system for more than a week
- Temporarily increases GHRH
Stacks well with:
Other growth hormone secretagogue peptides, with synergistic actions.
Ways to take:
Subcutaneous
Part of Koniver Protocols
- Neuroregen
- Flow
- Fat Loss
- Strength
- Performance
What is cerebrolysin and how does it work?
Cerebrolysin comes from an enzymatic fractionation of young pig brains. It consists of many neuroactive vitamins, short peptides, amino acids, and building blocks that support neuronal growth and function both in and outside the brain.
These active peptides include short snippets from brain-derived neurotrophic factor, nerve growth factor, ciliary nerve growth factor, P-21, enkephalins, glutathione, galanin, collagen, and orexins. Because all these components have low molecular weights, they cross the blood-brain barrier readily.
Benefits and uses
- Improves energy production, both inside and outside the mitochondria
- Protects neurons from oxidative stress, excess acidity, and excess glutamate
- Reduces amyloid deposition
- Improves synaptic function
- Improves glucose uptake into brain cells via Glut1 receptors
- Helps with cognitive function and behavioral performance
- Improves mood
- Supports recovery from concussions and brain injuries in combination with rehab programs and other treatments
Side effects
Cerebrolysin has been around since the 1950s. It is an approved medication in 44 countries (not yet in the US). The most often reported side effects include dizziness, headache, sweating, and nausea.
Stacks well with:
Use together or alternate with other nootropic peptides, such as Semax and selank.
Ways to take:
Short IV infusion (15 minutes)
Intramuscular injections
Subcutaneous injections
Part of Koniver Protocols
Currently cerebrolysin is available as a stand-alone peptide.
What is DIHEXA and how does it work?
DIHEXA is a small peptide derived from the hormone angiotensin IV. It crosses the blood-brain barrier readily and has neurotrophic activities. It targets hepatocyte growth factor (HGF), which is found in high density in the cortex.
Benefits and uses
- Improves cognitive function
- Supports recovery from brain trauma
- Boosts synapse formation
- Makes nerve signals stronger
- Improves brain blood flow
- Strengthens neuronal structure
- Helps with memory acquisition and consolidation
- Supports neural differentiation and regeneration
Side effects
Side effects of DIHEXA are rare, but may include:
- Changes in attention span
- Mood changes, which may include anxiety and irritability
- Sensory changes
- Insomnia
- Nausea
Stacks well with:
Can be alternated with Semax, Selank, and Cerebrolysin every six weeks
Ways to take:
Twice a day topically, although usage should be limited to no more than six weeks
Part of Koniver Protocols
Currently DIHEXA is only available as a stand-alone peptide.
What is Epithalon and how does it work?
Epithalon is the lab-made version of epithalamin, a natural pineal peptide hormone. It increases telomerase, an enzyme that helps extend the telomeres, which are the end of your chromosomes.
Telomere shortening is a marker of aging and can cause cellular senescence, when the cells can no longer divide and regenerate tissues.
Epithalon also helps with metabolism, hypothalamic sensitivity to hormones, and pituitary hormone productions. It increases lifespan in model organisms including flies, mice, and rats.
Benefits and uses
- Improves stress resistance
- Decelerates aging and cellular senescence
- Regulates and balances hormones
- Lengthens telomeres
- Reduces oxidative stress and lipid peroxidation
- Normalizes T cell function
- Protects neurons
- Normalizes melatonin loss due to aging
- Improves melatonin and cortisol circadian rhythm in older adults
- Promotes healthy DNA repair
- Improves insulin sensitivity
- Increases testosterone
- Stimulates the production of new neuron (neurogenesis)
Side effects
The most common reported side effects of Epithalon include redness and itchiness of injection sites, and hand and leg swelling.
Stacks well with:
Other anti-aging and anti-inflammatory peptides
Ways to take:
Subcutaneous injection
Part of Koniver Protocols
- Flow
- Apex
- Neuroregen
- Performance
What is GHRP-2 and how does it work?
Growth hormone is a natural peptide hormone from your pituitary gland. In young children, it stimulates growth. In adults, it supports muscle mass, fat metabolism, bone health, and heart health. It typically increases during deep sleep in the middle of the night. Also, its levels decline with age, contributing to age-related body fat gain, loss of lean mass, and slowed metabolism.
Growth hormone also stimulates IGF-1, which manages the effects of growth hormones. Both hormones work together on tissue and bone growth. IGF-1 weakly binds to insulin receptors and may enhance insulin action. In adults, IGF-1 also protects the blood vessels and neurons, making it important for cardiovascular health, and cognitive and mental health.
GHRPs (growth hormone releasing peptides) can boost natural growth hormone production from the anterior pituitary without the side effects of regular growth hormone supplementation. GHRP-2 is the second strongest GHRP. It binds to the growth hormone secretagogue receptor.
Aside from stimulating GH secretion, it stimulates ghrelin (hunger hormone), possibly helping with muscle gains. GHRP-2 also weakly and temporarily increases prolactin, ACTH, and cortisol.
Benefits and uses
- Promotes muscle growth
- Helps with mood and stress resilience
- Slows down aging
- Improves sleep
- Promotes a balanced inflammatory response
- Improves bone density
Side effects
- Redness, itchiness, and swelling of injection sites
- Stimulates ghrelin receptor and thus appetite (to a lesser extent than GHRP-6)
- Too high doses of GHRPs or use of GHRPs without cycling can overstimulate their receptors, reducing GH and its effectiveness
- Prolonged use and oversaturation of receptors may increase anxiety and depression
- Increases in stress responses through prolactin, and ACTH
- May cause hypoglycemia
Stacks well with:
- GHRH and other GHRPs
- BPC-157 for anabolic and tissue healing benefits
Ways to take:
Growth hormone secretagogues are best away from food, either before bed or first thing in the morning. They can be administered subcutaneously, orally, or intranasally.
Koniver Protocols
- Adonis
What is GHRP-6 and how does it work?
Growth hormone is a natural peptide hormone from your pituitary gland. In young children, it stimulates growth. In adults, it supports muscle mass, fat metabolism, bone health, and heart health. It typically increases during deep sleep in the middle of the night. Also, its levels decline with age, contributing to age-related body fat gain, loss of lean mass, and slowed metabolism.
Growth hormone also stimulates IGF-1, which manages the effects of growth hormones. Both hormones work together on tissue and bone growth. IGF-1 weakly binds to insulin receptors and may enhance insulin action. In adults, IGF-1 also protects the blood vessels and neurons, making it important for cardiovascular, and cognitive and mental health.
GHRP-6 is the third most potent GHRP. It doesn’t cause desensitization and also has less prolactin and cortisol issues than GHRP-2. It also binds to ghrelin receptors and stimulates appetite.
Benefits and uses
- Increases ghrelin in the stomach, stimulating hunger and appetite
- Increases lean mass
- Restores GH levels in obesity
- Improves stage 2 sleep
- Improves joint health
Side effects
- Strongly increases appetite
- Temporarily increases cortisol
- Redness and itchiness at injection site
- Swelling in the hands and legs
- Prolonged use and oversaturation of receptors may increase anxiety and depression
- Hot flashes
Stacks well with:
- Other GHRH and GHRPs
- BPC-157 for anabolic and tissue healing benefits
Ways to take:
Growth hormone secretagogues are best away from food, either before bed or first thing in the morning. They can be administered subcutaneously, orally, or intranasally.
Part of Koniver Protocols
- Strength
(Examorelin)
What is hexarelin and how does it work?
Growth hormone is a natural peptide hormone from your pituitary gland. In young children, it stimulates growth. In adults, it supports muscle mass, fat metabolism, bone health, and heart health. It typically increases during deep sleep in the middle of the night. Also, its levels decline with age, contributing to age-related body fat gain, loss of lean mass, and slowed metabolism.
Growth hormone also stimulates IGF-1, which manages the effects of growth hormones. Both hormones work together on tissue and bone growth. IGF-1 weakly binds to insulin receptors and may enhance insulin action. In adults, IGF-1 also protects the blood vessels and neurons, making it important for cardiovascular, and cognitive and mental health.
Hexarelin is a synthetic growth hormone-releasing peptide that stimulates GHRH release. It’s the strongest one that also increases cortisol and prolactin. However, it does not increase appetite, making it a helpful peptide for fat loss.
Benefits and uses
- Antagonizes somatostatin, allowing for muscle growth
- Potently stimulates the release of GHRH with longer lasting effect than GHRP-2 and GHRP-6
- Boosts mood
- Boosts stress resilience
- May protect neurons
- Improves bone growth
- Increases anabolism and tissue regeneration
Side effects
- Increases corticotropin-releasing hormone, cortisol, and prolactin
- Higher risk of desensitization
- Reduces delta brain wave and slow-wave (deep) sleep
- Injection site redness and itchiness
- Fluid retention in hands and legs
Stacks well with:
GHRPs
Ways to take:
Orally and subcutaneous injections
Part of Koniver Protocols
- Apex
- Performance
- Goddess
What is humanin and how does it work?
Humanin is a 24-amino acid peptide that naturally occurs in the mitochondria, found in many tissues and the bloodstream. It controls healthspan and lifespan in many animals. Natural humanin levels are higher in centenarians and their children compared to age-matched controls. Patients with Alzheimer’s, and mitochondrial encephalopathy, lactic acidosis and stroke-like episodes (MELAs) also had lower humanin levels.
In animals, humanin administration delays age-related cognitive and metabolic decline. At the same time, it protects against age-related diseases, such as stroke and cardiovascular conditions.
Benefits and uses
- Boosts mitochondria functions
- Improves lifespan and healthspan
- Improves metabolic parameters, reducing the risk of cardiovascular and metabolic diseases
- Reduces inflammatory markers
- Protects neurons
- Protects healthy cells from apoptosis (cellular suicide), while promoting apoptosis in cancer cells
Side effects
In experimental triple negative breast cancer in mice, humanin promoted tumor progression, so it may be contraindicated in cancer patients.
Stacks well with:
MOTS-c, NAD+
Ways to take:
Subcutaneous
Part of Koniver Protocols
- Super Mito Fitness
What is ipamorelin and how does it work?
Growth hormone is a natural peptide hormone from your pituitary gland. In young children, it stimulates growth. In adults, it supports muscle mass, fat metabolism, bone health, and heart health. It typically increases during deep sleep in the middle of the night. Also, its levels decline with age, contributing to age-related body fat gain, loss of lean mass, and slowed metabolism.
Growth hormone also stimulates IGF-1, which manages the effects of growth hormones. Both hormones work together on tissue and bone growth. IGF-1 weakly binds to insulin receptors and may enhance insulin action. In adults, IGF-1 also protects the blood vessels and neurons, making it important for cardiovascular, and cognitive and mental health.
Ipamorelin is a 5-amino acid peptide that stimulates the pituitary to secrete GH, boost IGF-1, and inhibit somatostatin. Therefore, it supports growth and repair of muscles.
It is the mildest and most popular GHRP because it can increase GH without desensitization or any increase in cortisol and prolactin even at large doses. It also doesn’t increase hunger. Therefore, it’s the most popular GH secretagogue.
Benefits and uses
- Increases growth hormone and IGF-1
- Suppresses somatostatin without increasing hunger
- Increases bone growth
- Supports muscle growth and repair
- Supports gut recovery after bowel resection
- Supports fat loss and body composition in combination with the right training and nutrition
Side effects
Side effects can include redness and itchiness of the injection sites and hand and feet swelling.
Stacks well with:
Other GHRH and GH secretagogues
Ways to take:
Subcutaneous
Part of Koniver Protocols
- Flow
- Fat Loss
- Performance
What is kisspeptin and how does it work?
Kisspeptin is a neuropeptide hormone from the hypothalamus that stimulates the release of gonadotropin-releasing hormone (GnRH) from hypothalamic neurons through a receptor called GPR54. It helps normalize steroid hormone feedback and responses to nutrients.
Naturally-occuring kisspeptin helps stimulate sexual arousal and romance in men. It may also boost fertility outcomes and psychosexual mental health issues related to conception efforts. Kisspeptin is being researched as a potential alternative to hCG in fertility treatments.
In animal models of polycystic ovarian syndrome, kisspeptin and GnRH levels are abnormal.
Benefits and uses
- Helps with infertility and hormones
- Stimulates the hypothalamic-pituitary-gonadal axis via the GPR54 receptors
- Stimulates hypothalamic GnRH release to increase LH and FSH, in turn boosting estrogen, progesterone, and testosterone
- Increases both basal- and hCG-stimulated progesterone secretion from luteal phase uterine cells
- Increases liver antioxidants
- Boosts insulin secretion
- Temporarily increases oxytocin
Side effects
No side effects have been reported in clinical studies.
Stacks well with:
Other sexual health peptides, such as PT-141
Ways to take:
Subcutaneous
Part of Koniver Protocols
- Vitality
What is KPV and how does it work?
KPV is a 3-amino acid peptide, lysine-proline-valine, which is a segment of melanocyte-stimulating hormone (MSH). MSH has circadian rhythm functions and anti-inflammatory properties.
KPV can enter the cells and nucleus, where your DNA is. There, it can inhibit NF-kB, your cell’s main controller of inflammatory pathways.
Benefits and uses
- Inhibits NF-kB and inflammatory MAPK signaling
- Reduces inflammatory cytokines
- Promotes a balanced inflammatory response, especially in the gut
- Promotes wound healing
- May have antimicrobial activities
- Improves skin health and regeneration
Side effects
No side effects of KPV have been reported.
Stacks well with:
Other Healing And Anti-Inflammatory Peptides, Such As BPC-157 And GHK-Cu
Ways to take:
- Subcutaneous
- Oral
- Transdermal
Part of Koniver Protocols
- Revive
What is LL-37 and how does it work?
LL-37 is the 37-amino acid cleavage product of human cathelicidin, an antiviral, antimicrobial, and anti-biofilm peptide. Humans produce the precursor form of this peptide in our neutrophils, natural killer cells, and in the lung lining cells.
Because LL-37 is positively charged, it can cling to and poke holes in negatively-charged bacterial cells and viral membranes. It can block the bacterial toxin called lipopolysaccharides from causing inflammation through Toll-like receptors. With its interaction with cell membranes, it can help modulate immune function.
Benefits and uses
- Help Fights Some Infections, Especially Respiratory
- Blocks Lipopolysaccharides From Interacting With TLR4 Receptors, So It Can Mitigate Metabolic Endotoxemia, And Inflammation From High-Fat Meals And Gram-Negative Bacteria
- Reduces Th2 Cytokines
- Protects Against Gut Inflammation From Gut Infections
- Helps Call Other Immune Cells To The Site
- Promotes A Balanced Immune Response
- Inhibits Macrophages’ Fever-Producing Activities
Side effects
Although no side effects of LL-37 have been reported in the literature, and LL-37 isn’t known to cause any disease, high LL-37 is found in patients with autoimmune diseases and atherosclerosis. Those with these conditions or who are at high risk should consult their physician before using LL-37.
Stacks well with:
Other immune peptides such as TB-500 and thymosin alpha 1.
Ways to take:
Subcutaneous, intranasal
Part of Koniver Protocols
- Armor
What is MGF and how does it work?
MGF stands for mechano growth receptor. It’s made from parts of the IGF-1 gene, typically by mechanically overloaded muscles. The main benefit of MGF is to stimulate muscle growth, especially in tissue repair and adaptation after resistance training.
MGF as external peptides have polyethylene glycol chemically attached to them to increase their half-life and overall benefits.
Benefits and uses
- Stimulates muscle growth by activating muscle stem cells (satellite cells)
- Helps with muscle repair after exercise and during muscle stress and injury
- Supports healthy bones, joints, and their regeneration
- Protects neurons and counteracts age-related neuronal degeneration
- Supports healthy neuronal regeneration
Side effects
Side effects of MGF are rare and may happen at excessive doses. Potential side effects include low blood sugar and swelling of extremities.
Stacks well with:
Other anabolic peptides and growth hormone secretagogues, Semax, BPC-157
Ways to take:
- Subcutaneous
- Injection into joints (for joint indications)
Part of Koniver Protocols
- Apex
- Strength
What is MOTS-c and how does it work?
MOTS-c is a 16-amino acid mitochondrial peptide produced mainly in muscles. It’s also detectable in other tissues and in the blood.
Exercise generally boosts MOTS-c levels, so MOTS-c administration replicates many of the benefits of exercise.
Benefits and uses
- Protects the cells
- Maintains mitochondrial function and cellular viability under stressful conditions
- Regulates metabolic homeostasis
- May mitigate diet-induced insulin resistance and obesity
- Inhibits purine biosynthesis
- Activates 5’adenosine monophosphate-activated protein kinase (AMPK), increasing fat oxidation
- Increases transport of fatty acids into the mitochondria to burn for energy
- Increases fat burning and reduces production of new fat molecules
- Improves glucose uptake by bringing glucose transporter 4 (Glut4) in muscles
- Activates peroxisome proliferator-activated receptor-gamma coactivator (PGC-1alpha), which increases the generation of new and healthy mitochondria.
- PGC-1alpha then activates nuclear respiratory factors (Nrf1 and Nrf2), which turns on many antioxidant genes.
- Increases calorie burn as heat production by increasing brown fat and mitochondrial uncoupling using uncoupling protein 1 (UCP-1)
- Preserves mitochondrial function and bone mass in a mouse menopause model, with biochemical effects similar to exercise
- Improves athletic performance
- Supports weight loss effort in combination with diet and exercise
- May improve strength and muscle gain by modulating myostatin
- Protects against memory impairment from amyloid beta and lipopolysaccharides (inflammatory bacterial toxins from leaky gut) in a mouse model with intranasal delivery
- May boost longevity
Side effects
No side effects have been reported in clinical trials.
Stacks well with:
Can be cycled with other mitochondrial peptide
Ways to take:
Subcutaneous and intranasal
Part of Koniver Protocols
- Super Mito Fitness
- Fat Burner + Peptide Protocol
What is PE-22-28 and how does it work?
PE-22-28 is a 7-amino acid derivative of Spadin, which blocks the TREK-1 channel in the brain. Chronic, unpredictable mild stress increases TREK-1 in the hippocampus, a region that controls mood, memory, and learning. The TREK-1 increase may allow for stress-induced cognitive impairment and low mood, so blocking it seems to preserve cognitive performance and mood during stress. Mice studies showed that PE-22-28 reduced immobility time and delay to eating food. It also boosts neuronal growth and connections, and protects neurons from excitotoxicity.
Benefits and uses
- Improves mood and motivation
- Induces neurogenesis and synaptogenesis
- Improves firing rates of serotonin neurons
- Protects neurons from excess glutamate
- Improves the brain’s stress resilience
- Preserves cognitive performance amidst stress
Side effects
PE-22-28 is well-tolerated, and so far no side effects have been reported.
Stacks well with:
Other neuroregenerative peptides
Ways to take:
Oral and subcutaneous
Part of Koniver Protocols
- Neuroregen
What is pinealon and how does it work?
Pinealon is a 3-amino acid peptide that can reverse brain aging and protect brain tissues against hypoxia and cellular suicide (apoptosis). Due to its small size, it can cross the blood-brain barrier. Once it enters the cells, it can directly interact with DNA and change genetic readouts.
Benefits and uses
- Helps with memory and attention
- Protects neurons against damages and oxidative stress, including from lack of oxygen or blood flow
- Promotes neurogenesis
- Geroprotective and anabolic
- Increases cellular resistance to oxidative damage and counteracts oxidative stress
- May protect the brain from high homocysteine, a neurotoxic amino acid
- Protects muscle cells from damage during exercise
- Stimulates weight loss
- May increase serotonin levels
- Promotes healthy circadian rhythm and improves sleep
- Improves red blood cell membrane health and reduces lipid peroxidation
- Boosts mood and brain function
Side effects
No side effects have been reported in clinical trials.
Stacks well with:
other anti-aging and melanocortin peptides
Ways to take:
subcutaneous and oral
Part of Koniver Protocols
- Apex
- Vitality
What is PT-141 (bremelanotide) and how does it work?
PT-141 is a libido-boosting peptide. It’s a synthetic peptide analog of alpha-MSH, which is a neurohormone in the melanocortin system. It works by activating the MC3R and MC4R receptors in the brain. Intranasal use of this peptide causes erection in many animals and humans. However, PT-141 doesn’t cause the drop in blood pressure, unlike current erectile drugs, suggesting that it doesn’t work through the cardiovascular system.
The melanocortin system controls metabolism and appetite, along with heart health, stress response, and sexual function. Alpha-melanocyte stimulating hormone (alpha-MSH) can modulate the nervous and immune systems. It also has anti-inflammatory and anti-microbial activities.
In the skin, alpha-MSH also influences skin darkness. However, unlike melanotan 2, PT-141 does not cause skin darkening.
Benefits and uses
- Increases sexual desire, motivation, and arousal across genders
- Induces erectile response
- Improves genital sensation and pleasure
- May help with discomfort and orgasm during intercourse
- May help with emotional issues around sex
- Improves heart health and metabolism
- Promotes healthy blood pressure
- Promotes healthy stress response
Side effects
Side effects can include flushing and nausea and redness and irritation around the injection site.
Stacks well with:
other sexual health peptides such as kisspeptin.
Ways to take:
Intranasal and subcutaneous
Part of Koniver Protocols
- Goddess
- Vitality
What is thymalin and how does it work?
Thymalin is a mix of peptides from the thymus that can help regulate immune function and support the body’s natural ability to fight infections. It is also geroprotective, anti-aging, and may protect against all-cause mortality.
In mice, thymalin reduces all-cause mortality and prolongs lifespan.
Benefits and uses
- Supports a balanced immune response
- Promotes immune system readiness
- Regulates circadian rhythm and sleep-wake cycle
- May reduce all-cause mortality
- Supports healthy recovery from respiratory illnesses
Side effects
No side effects have been identified in clinical studies.
Stacks well with:
Other pineal, immune, and tissue healing peptides
Ways to take:
Subcutaneous
Part of Koniver Protocols
- Flow
- Apex
What is thymosin beta-4 and how does it work?
Thymosin beta-4 is a 43-amino acid derivative of thymosin, a hormone from the thymus that stimulates T cell production. However, TB-500 is naturally found in most cells. Naturally, the gene that produces this peptide tends to be the first to become dysregulated after injuries.
It can control how actin forms strands that provide structures to the cells. In animal studies, it promoted the formation of new blood vessels, wound repair, and hair growth.
Benefits and uses
- Promotes wound and tissue healing
- Increases blood vessel formation
- Promotes hair growth, especially in conjunction with PRP
- Promotes Th1/Th2 balance
Side effects
Side effects include temporary fatigue and lethargy. Although there is no evidence that this peptide causes cancer, there are concerns that it can contribute to carcinogenesis.
Stacks well with:
Other immune and healing peptides, such as thymosin alpha 1 and BPC-157
Ways to take:
Subcutaneous
Part of Koniver Protocols
- Apex
- Equilibrium
- Glow
What is tesamorelin and how does it work?
Growth hormone is a very important anti-aging hormone that helps with cell growth and metabolic efficiency. It also helps with the production of IGF-1 to reproduce and regenerate cells. But your body has a negative feedback system for growth hormone, so injecting GH leads to too much IGF-1, which accelerates cellular aging.
Whereas, growth hormone-releasing hormone (GHRH) gently stimulates the pituitary to release growth hormones without activating the negative feedback. So, you can get the anti-aging, muscle-building, and fat-loss benefits of growth hormone without the side effects of growth hormone injections.
Tesamorelin is a GHRH that increases IGF-1 without disrupting its negative feedback loop. It was initially approved to treat HIV-associated lipodystrophy (increase in mid-section fat between organs due to antiretroviral drugs).
Benefits and uses
- Helps with bone density
- Supports muscle and lipid metabolism
- Promotes a balanced inflammatory response
- Supports heart health
- Helps with fat loss, especially belly fat and dangerous fat between organs
- Boosts cognitive function
- Improves cognitive function in seniors with age-related cognitive decline and mild cognitive impairment, including those with ApoE4 gene
Side effects
- Increases IGF-1 (when not desired)
- May cause glucose intolerance and increase the risk of diabetes
- Injection site redness, irritation, and itchiness
- Muscle aches
- Hand and leg swelling
- Contraindicated in pregnancy and those with pituitary conditions
Stacks well with:
- Ipamorelin
- CJC-1295
- Hexarelin
Ways to take:
Subcutaneous injection
Part of Koniver Protocols
- Fat Loss
- Goddess
What is Selank (TP-7) and how does it work?
Selank is a 7-amino acid peptide created by joining Tuftsin with another three amino acids to make it more stable. As a synthetic analog of Tuftsin, a 4-amino acid that is part of immunoglobulin G, it has some immune-stimulating effects.
Benefits and uses
- Anti-ulcer and promotes a strong gut mucosal barrier
- Promotes healthy relaxation response by increasing the effects of GABA
- Increases BDNF in the hippocampus, possibly boosting mood and cognitive function
- Improves sleep vs. wakefulness balance
- Helps regulate inflammation, especially through IL-6 and helper T cells
- Regulates monoamine neurotransmitters
- Regulates BCL-6, which controls T cell-mediated immune responses
- Supports antiviral immune function
- Helps with insulin resistance and metabolism
Side effects
Excess doses can lead to desensitization.
Stacks well with:
- Can be alternate with Semax.
- Other immune peptides such as TB-500 and thymosin alpha 1.
Ways to take:
Subcutaneous and intranasal
Part of Koniver Protocols
- Armor
- Goddess
- Apex
What is Semax and how does it work?
Semax is a 7-amino acid peptide that comes from amino acids 4 – 10 of the adrenocorticotropic hormone (ACTH). Typically, the body produces ACTH as a stress hormone, but Semax in particular has many unique properties, such as stimulating neuronal growth and immune function. It’s said to induce the good parts of stress, such as the high and enhanced performance, without the anxiety. So, you can perform and learn with minimal resistance and procrastination.
As a melanocortin, it acts at many places throughout the body, which is why it helps with the immune system, gut health, and brain function.
N-acetyl semax is a synthetic form that is better absorbed and can better cross the blood-brain barrier.
Benefits and uses
- Increases BDNF
- Increases dopamine and serotonin signaling, boosting mood and motivation
- Improves stress resilience and promotes a balanced stress response
- Blocks melanocortin receptors (MC3R and MC4R)
- Boosts immune function efficiency
- Protects neurons and supports neuronal healing
- Supports the healing processes of the stomach lining
- May be used preventively
- Thins the blood
- Improves physical performance and adaptation to high-intensity exercise
- Improves memory, focus, attention span, and verbal fluency
- Improves blood flow to the brain
- May block pain signaling through enkephalin
- Protects delicate neurons in the eyes
- May facilitate lucid dreaming
- May potentiate other stimulants
- Boosts confidence and wellbeing
- Antioxidant properties
Side effects
- Excess and prolonged use can lead to desensitization.
- Hair loss
- The effects tend to last a few hours. Susceptible people may feel low mood and motivation once the effects wear off, so people with pre-existing mental health conditions should consult their physician before use
Stacks well with:
- other nootropic peptides such as cerebrolysin
- May be alternated with Selank
Ways to take:
Subcutaneous and intranasal
Part of Koniver Protocols
- Apex
- Adpnos
- Strength (N-acetyl form)
Frequently Asked Questions
Peptide Protocols were developed by Craig Koniver, MD because they are very, very safe with no side effects and they can, when properly administered, communicate with different specific parts of the body, therefore potentially enhancing the function of the entire body by binding to receptors on the cell surface and signaling optimal messages for health improvement.
We recommend focusing on one protocol at a time, but certain protocols can be utilized simultaneously. Please contact us if you would like to inquire about the use of more than one protocol together.
Peptides are generally very, very safe to use and well-tolerated as there are over 7,000 naturally-occurring peptides in the body that have been identified.
There are a variety of different benefits of using Peptide Protocols, and they differ with which Protocol you decide to use. From peptides that help with muscle building, to ones that help develop radiant skin and reverse aging, to ones that help correct sleep issues, there is a vast range of ailments and concerns that these protocols can help with.
Administering the peptides is virtually painless, as they are injected subcutaneously using a very small insulin needle.
Yes, we offer tutorial videos of how to properly administer peptides.
